New 2nd generation vaccine includes 2 Covid proteins for broader immune response
University of Cape Town (UCT) researchers are expected to start a phase one clinical trial of the Covid-19 vaccine candidate, hAd5 T-cell, later this month explains John Maytham.
Professor Graeme Meintjes of the Department of Medicine at UCT and a co-investigator on the trial talks to John about the research.
Meintjies explains what makes this vaccine different from others such as the Johnson&Johnson, AstraZeneca, and others that have come through clinical trials and are now being rolled out across the world.
This is a second-generation vaccine, and most of the vaccines we have been hearing about have one protein target.Professor Graeme Meintjies, Co-investigator - Dept of Medicine, UCT
In those examples, one protein is taken from the SARS-CoV-2 virus and includes it in the vaccine and exposes the immune system to that, he explains.
In this vaccine, there are two proteins from the Covid virus, so by including two proteins you are getting a broader immune response. So, it is not just the spiked protein - it is the spiked protein plus the nucleocapsid protein, the protein found inside the virus.Professor Graeme Meintjies, Co-investigator - Dept of Medicine, UCT
Why were both proteins not targeted in the original vaccine research, asks John?
Meintjies says he suspects it was the need for speed to get the vaccine ready, and also the virus has mutated faster than anticipated.
Listen to the interview in the audio below:
Source : https://www.123rf.com/photo_119153994_vial-of-new-vaccine.html
The allegations have been made by an actress who claims the Oscar-nominated star raped her at her home three years ago.Read More
The champion golfer flipped his vehicle several times and has seriously injured both his legs.Read More
The opportunity is a game-changer for the fledgling SA bank. Bruce Whitfield interviews TymeBank CEO Tauriq Keraan.Read More
Mail & Guardian contributor Robyn Porteus says practical solutions need to be prioritised.Read More
Every adult in the UK will be offered a Covid-19 jab by the end of July as authorities ramp up the vaccination programme.Read More
A South African living in Texas says it has been a tough week for his neighbourhood which had no power for 36 hours due to a winter storm.Read More
Ocean adventurer Chris Bertish is gearing up for another world-first ocean crossing - wing foiling across the Pacific Ocean from California to Hawaii.Read More
The abuses included coercing or paying birth mothers in places like Indonesia, Brazil, and Columbia to give up children.Read More
The untapped potential of Africa’s treasure trove of natural wealth presents its beneficiaries with a prosperous future, if exploited.Read More
The proposal to tax retirement fund members when no longer tax-resident in SA is not unreasonable, says Prof. Osman Mollagee.Read More
Consumer ninja Wendy Knowler follows up on the case of a patient who'd been paying his membership dues for more than 40 years.Read More
'We owe a lot of people a lot of money' says Tito Mboweni. Wide-ranging reaction to Budget 2021 on The Money Show.Read More
The Western Cape Health Department says it's implementing additional security measures after reports of vaccine queue-jumping in the province.Read More
Kim Prytz took six hours to complete the swim from Robben Island to Melkbos, raising money for vulnerable families in Capricorn.Read More
An organ transplant recipient in the US died of Covid-19 two months after contracting the virus from her donor's infected lungs.Read More
Ron Martin of the South African Heritage Resources Agency says the art is valuable beyond estimation.Read More
The Karl Bremer Hospital near Belville is the lastest site where healthcare workers are able to receive Covid-19 vaccines in the metro.Read More
All eyes were on South African Finance Minister Tito Mboweni as he delivers his 2021 Budget Speech on Wednesday at 2pm.Read More
Jacobs Jam Company is a level 1 B-BBEE, female, youth-owned jam and sauce manufacturer, located in Ceres.Read More